Disordered plasticity in the primary somatosensory cortex in focal hand dystonia
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چکیده
منابع مشابه
Disordered plasticity in the primary somatosensory cortex in focal hand dystonia.
Interventional paired associative stimulation (PAS) can induce plasticity in the cortex, and this plasticity was previously shown to be disordered in the primary motor cortex in focal hand dystonia (FHD). This study aimed to test whether associative plasticity is abnormal in the primary somatosensory cortex (S1) in FHD and whether PAS modulates excitatory or inhibitory interneurons within the c...
متن کاملCortical Activation in the Primary Somatosensory Cortex: Healthy and Diagnosed Focal Hand Dystonia
Current documentation on the pathophysiology of focal hand dystonia (FHD) is not conclusive regarding cortical activation. Most importantly, previous studies have not focused reports on the relative activation between hemispheres with stimulation of both hands. Purpose: to determine and compare the blood oxygen level dependent (BOLD) signal changes within primary somatosensory cortex (S1) durin...
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The excitability of inhibitory circuits in patients with writer's cramp is reduced at multiple levels within the sensorimotor system, including the primary motor hand area (M1). Although this may play a major role in the pathophysiology of writer's cramp, it is still unclear what factors may cause the imbalance between inhibition and excitation to arise. One possibility is that homeostatic mech...
متن کاملAlteration of digital representations in somatosensory cortex in focal hand dystonia.
Focal hand dystonia involves a loss of motor control of one or more digits; it is associated with the repetitive, synchronous movements of the digits made by musicians over periods of many years. Magnetic source imaging revealed that there is a smaller distance (fusion) between the representations of the digits in somatosensory cortex for the affected hand of dystonic musicians than for the han...
متن کاملReorganization of the Human Somatosensory Cortex in Hand Dystonia
BACKGROUND AND PURPOSE Abnormalities of finger representations in the somatosensory cortex have been identified in patients with focal hand dystonia. Measuring blood flow with positron emission tomography (PET) can be use to demonstrate functional localization of receptive fields. METHODS A vibratory stimulus was applied to the right thumb and little finger of six healthy volunteers and six p...
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ژورنال
عنوان ژورنال: Brain
سال: 2009
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awn348